Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Although several studies have addressed plasma proteomics in heart failure with preserved ejection fraction, limited data are available on the prognostic value of urinary proteomics. The objective of our study was to identify urinary proteins/peptides associated with death and heart failure admission in patients with heart failure with preserved ejection fraction.

Methods and results

The study population included participants enrolled in TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial). The relationship between urine protein levels and the risk of death or heart failure admission was assessed using Cox regression, in both nonadjusted analyses and adjusting for urine creatinine levels, and the MAGGIC (Meta-Analysis

SUBMITTER: Carland C 

PROVIDER: S-EPMC11179922 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature