Structural basis of neuropeptide Y signaling through Y₁ and Y₂ receptors.

ABSTRACT: Neuropeptide Y (NPY), a 36-amino-acid peptide, functions as a neurotransmitter in both the central and peripheral nervous systems by activating the NPY receptor subfamily. Notably, NPY analogs display varying selectivity and exert diverse physiological effects through their interactions with this receptor family. [Pro³⁴]-NPY and [Leu³¹, Pro³⁴]-NPY, mainly acting on Y₁R, reportedly increases blood pressure and postsynaptically potentiates the effect of other vasoactive substances above all, while N-terminal cleaved NPY variants in human body primary mediates angiogenesis and neurotransmitter release inhibition through Y₂R. However, the recognition mechanisms of Y₁R and Y₂R with specific agonists remain elusive, the

SUBMITTER: Shen S 

PROVIDER: S-EPMC11179954 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature