Non-canonical Wnt pathway expression in the developing mouse and human retina.

ABSTRACT: The non-canonical Wnt pathway is an evolutionarily conserved pathway essential for tissue patterning and development across species and tissues. In mammals, this pathway plays a role in neuronal migration, dendritogenesis, axon growth, and synapse formation. However, its role in development and synaptogenesis of the human retina remains less established. In order to address this knowledge gap, we analyzed publicly available single-cell RNA sequencing (scRNAseq) datasets for mouse retina, human retina, and human retinal organoids over multiple developmental time points during outer retinal maturation. We identified ligands, receptors, and mediator genes with a putative role in retinal development, including those with novel or species-specific expression, and validated this expression using

SUBMITTER: Campos RC 

PROVIDER: S-EPMC11179970 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature