2D CAIPI accelerated 3D multi-slab diffusion weighted EPI combined with qModeL reconstruction for fast high resolution microstructure imaging.

ABSTRACT:

Purpose

To develop acceleration strategies for 3D multi-slab diffusion weighted imaging (3D ms-DWI) for enabling applications that require simultaneously high spatial (1 mm isotropic) and angular (> 30 directions) resolutions.

Methods

3D ms-DWI offers high SNR-efficiency, with the ability to achieve high isotropic spatial resolution, yet suffers from long scan-times for studies requiring high angular resolutions. We develop 6D k-q space acceleration strategies to reduce the scan-time. Specifically, we develop non-uniform 3D k_y-k_z under-sampling employing a shot-selective 2D CAIPI sampling approach. To achieve inter-shot phase-compensation, 2D navigators were employed that utilize the same CAIPI trajectory. An iterative model-based 3D multi-shot reconstr

SUBMITTER: Lee CY 

PROVIDER: S-EPMC11179987 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature