Prostaglandin E2 affects mitochondrial function in adult mouse cardiomyocytes and hearts.

ABSTRACT: Prostaglandin E2 (PGE2) signals differently through 4 receptor subtypes (EP1-EP4) to elicit diverse physiologic/pathologic effects. We previously reported that PGE2 via its EP3 receptor reduces cardiac contractility and male mice with cardiomyocyte-specific deletion of the EP4 receptor (EP4 KO) develop dilated cardiomyopathy. The aim of this study was to identify pathways responsible for this phenotype. We performed ingenuity pathway analysis (IPA) and found that genes differentiating WT mice and EP4 KO mice were significantly overrepresented in mitochondrial (adj. p value = 6.28 × 10^-26) and oxidative phosphorylation (adj. p value = 1.58 × 10^-27) pathways. Electron microscopy from the EP4 KO hearts show substantial mitochondrial disarray and disordered cristae. Not s

SUBMITTER: Bryson TD 

PROVIDER: S-EPMC11180573 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature