Identification and validation of the role of ZNF281 in 5-fluorouracil chemotherapy of gastric cancer.

ABSTRACT:

Background

The early diagnosis of gastric cancer (GC) and overcoming chemotherapy resistance is challenging. The aberrant expression of zinc finger protein 281 (ZNF281) and the over-activation of the Wnt/β-catenin pathway are oncogenic factors and confer tumor chemoresistance. ZNF281 modulates the Wnt/β-catenin pathway to influence malignant tumor behavior. However, the role of ZNF281 in GC chemotherapy and the relationship with the Wnt/β-catenin pathway have not been elucidated by researchers.

Methods

We explored differences in ZNF281 expression in Pan-cancer and normal tissues, the effect of its expression on prognosis of patients treated with 5-fluorouracil (5-FU). Cox regression was utilized to determine whether ZNF281 is an independent prognostic factor. Enrichment anal

SUBMITTER: Li Y 

PROVIDER: S-EPMC11180638 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature