Circulating immune cells and vitiligo: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

The pathogenesis of vitiligo remains elusive. Emerging evidence suggests that vitiligo is an immune-mediated disorder, in which a plethora of immune cells play pivotal roles. However, the association between circulating immune cells and vitiligo continues to be enigmatic.

Materials and methods

We extracted single nucleotide polymorphisms (SNPs) associated with immune circulating cells at a genome-wide significance level from the BLOOD CELL CONSORTIUM's genome-wide association study (GWAS) dataset. Summary data for 385,801 cases of vitiligo were obtained from a large-scale Finnish genome-wide association study (ncases=292, ncontrols=385,509). The inverse variance weighted (IVW) method was employed as the primary analytical approach for Mendelian randomization (MR)

SUBMITTER: Xin Y 

PROVIDER: S-EPMC11180719 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature