The impact of abstinence from chronic alcohol consumption on the mouse striatal proteome: sex and subregion-specific differences.

ABSTRACT: Alcohol misuse is the third leading preventable cause of death in the world. The World Health Organization currently estimates that 1 in 20 deaths are directly alcohol related. One of the ways in which consuming excessive levels of alcohol can both directly and indirectly affect human mortality and morbidity, is through chronic inflammation. Recently, studies have suggested a link between increased alcohol use and the incidence of neuroinflammatory-related diseases. However, the mechanism in which alcohol potentially influences neuroinflammatory processes is still being uncovered. We implemented an unbiased proteomics exploration of alcohol-induced changes in the striatum, with a specific emphasis on proteins related to inflammation. The striatum is a brain region that is critically involv

SUBMITTER: Duffus BM 

PROVIDER: S-EPMC11180734 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature