Causal relationship between T2DM microvascular complications and gut microbiota: a Mendelian randomization study.

ABSTRACT:

Background

Gowing number of studies have demonstrated the association between gut microbiome and T2DM microvascular complications, however the causal relationship remains unclear. Therefore, we using the Mendelian randomization (MR) approach to investigate this causal relation.

Methods

Using gut microbiome data from the International MiBioGen Consortium genome-wide association study (GWAS) and T2DM microvascular complications data from the FinnGen Consortium GWAS to perform MR analyses. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs), the inverse variance weighting (IVW) method was used as the primary analysis method, and the results were tested for heterogeneity and horizontal pleiotropy.

Results

Our research identified that there

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11180823 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature