Echocardiographic measures of the left heart and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: The CABLE study.

ABSTRACT:

Introduction

This study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer's disease (AD) biomarkers, and cognition.

Methods

Multiple linear regressions were conducted in 1244 cognitively normal participants (mean age = 65.5; 43% female) who underwent echocardiography (left atrial [LA] and left ventricular [LV] morphologic or functional parameters) and CSF AD biomarkers measurements. Mediating effects of AD pathologies were examined. Differences in cardiac parameters across ATN categories were tested using analysis of variance (ANOVA) and logistic regressions.

Results

LA or LV enlargement (characterized by increased diameters and volumes) and LV hypertrophy (increased interventricular septal or pos

SUBMITTER: Hu HY 

PROVIDER: S-EPMC11180853 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature