Transcriptional and functional remodeling of lung-resident T cells and macrophages by Simian varicella virus infection.

ABSTRACT:

Introduction

Varicella zoster virus (VZV) causes varicella and can reactivate as herpes zoster, and both diseases present a significant burden worldwide. However, the mechanisms by which VZV establishes latency in the sensory ganglia and disseminates to these sites remain unclear.

Methods

We combined a single-cell sequencing approach and a well-established rhesus macaque experimental model using Simian varicella virus (SVV), which recapitulates the VZV infection in humans, to define the acute immune response to SVV in the lung as well as compare the transcriptome of infected and bystander lung-resident T cells and macrophages.

Results and discussion

Our analysis showed a decrease in the frequency of alveolar macrophages concomitant with an increase in that of infiltra

SUBMITTER: Doratt BM 

PROVIDER: S-EPMC11180879 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature