Cognitively healthy centenarians are genetically protected against Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages > 100 years without cognitive decline. We studied the genetic factors associated with such resilience against AD.

Methods

Genome-wide association studies identified 86 single nucleotide polymorphisms (SNPs) associated with AD risk. We estimated SNP frequency in 2281 AD cases, 3165 age-matched controls, and 346 cognitively healthy centenarians. We calculated a polygenic risk score (PRS) for each individual and investigated the functional properties of SNPs enriched/depleted in centenarians.

Results

Cognitively healthy centenarians were enriched with the protective alleles of the SNPs associated with AD risk. The protective effect concentrated on the al

SUBMITTER: Tesi N 

PROVIDER: S-EPMC11180929 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature