ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.

ABSTRACT: Follicular helper T (T_FH) cells mediate germinal center reactions to generate high affinity antibodies against specific pathogens, and their excessive production is associated with the pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE). ETV5, a member of the ETS transcription factor family, promotes T_FH cell differentiation in mice. In this study, we examined the role of ETV5 in the pathogenesis of lupus in mice and humans. T cell-specific deletion of Etv5 alleles ameliorated T_FH cell differentiation and autoimmune phenotypes in lupus mouse models. Further, we identified SPP1 as an ETV5 target that promotes T_FH cell differentiation in both mice and humans. Notably, extracellular osteopontin (OPN)

SUBMITTER: Park J 

PROVIDER: S-EPMC11181037 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature