Developmental hearing loss-induced perceptual deficits are rescued by genetic restoration of cortical inhibition.

ABSTRACT: Even a transient period of hearing loss during the developmental critical period can induce long-lasting deficits in temporal and spectral perception. These perceptual deficits correlate with speech perception in humans. In gerbils, these hearing loss-induced perceptual deficits are correlated with a reduction of both ionotropic GABA_A and metabotropic GABA_B receptor-mediated synaptic inhibition in auditory cortex, but most research on critical period plasticity has focused on GABA_A receptors. Therefore, we developed viral vectors to express proteins that would upregulate gerbil postsynaptic inhibitory receptor subunits (GABA_A, Gabra1; GABA_B, Gabbr1b) in pyramidal neurons, and an enzyme that mediates GABA synthesis (GAD

SUBMITTER: Masri S 

PROVIDER: S-EPMC11181144 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature