Association of early menarche with breast tumor molecular features and recurrence.

ABSTRACT:

Background

Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains unclear.

Methods

We profiled transcriptome-wide gene expression in breast tumors (N = 846) and tumor-adjacent normal tissues (N = 666) from women in the Nurses' Health Studies (NHS) to investigate whether early menarche (age < 12) is associated with tumor molecular and prognostic features in women with breast cancer. Multivariable linear regression and pathway analyses using competitive gene set enrichment analysis were conducted in both tumor and adjacent-normal tissue and externally validated in TCGA (N = 116). Subgroup analyses stratified on ER-status based on the tumor were also performed. PAM50 signatures were used for tumor mol

SUBMITTER: Harris AR 

PROVIDER: S-EPMC11181557 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature