Short-chain fatty acid valerate reduces voluntary alcohol intake in male mice.

ABSTRACT:

Background

Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. The development of novel therapeutic and preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between the gut microbiome and microbial metabolites with drinking behavior, but druggable targets and their underlying mechanism of action are understudied.

Results

Here, using a drink-in-the-dark mouse model, we identified a microbiome metabolite-based novel treatment (sodium valerate) that can reduce excessive alcohol drinking. Sodium valerate is a sodium salt of valeric acid short-chain fatty acid with a similar structure as γ-aminobutyric acid (GABA). Ten days of oral so

SUBMITTER: Bokoliya SC 

PROVIDER: S-EPMC11181657 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature