Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers.

ABSTRACT:

Background

Somatic copy number alterations are a hallmark of cancer that offer unique opportunities for therapeutic exploitation. Here, we focused on the identification of specific vulnerabilities for tumors harboring chromosome 8p deletions.

Methods

We developed and applied an integrative analysis of The Cancer Genome Atlas (TCGA), the Cancer Dependency Map (DepMap), and the Cancer Cell Line Encyclopedia to identify chromosome 8p-specific vulnerabilities. We employ orthogonal gene targeting strategies, both in vitro and in vivo, including short hairpin RNA-mediated gene knockdown and CRISPR/Cas9-mediated gene knockout to validate vulnerabilities.

Results

We identified SLC25A28 (also known as MFRN2), as a specific vulnerability for tumors harboring chromosome 8p delet

SUBMITTER: Krieg S 

PROVIDER: S-EPMC11181659 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature