Circulating TMAO, the gut microbiome and cardiometabolic disease risk: an exploration in key precursor disorders.

ABSTRACT:

Background

Elevations in the gut metabolite trimethylamine-N-oxide (TMAO) have been linked to cardiovascular and metabolic diseases. Whether elevated TMAO levels reflect early mechanistic involvement or a sequela of evolving disease awaits elucidation. The purpose of this study was to further explore these potential associations.

Methods

We investigated relationships between circulating levels of TMAO and its pre-cursor substrates, dietary factors, gut microbiome profiles and disease risk in individuals with a Healthy BMI (18.5 < BMI < 25, n = 41) or key precursor states for cardiometabolic disease: Overweight (25 < BMI < 30 kg/m², n = 33), Obese (BMI > 30, n = 27) and Metabolic Syndrome (MetS; ≥ 3 ATPIII report criteria, n = 39).

Results

Unexpectedly, plas

SUBMITTER: Naghipour S 

PROVIDER: S-EPMC11181661 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature