Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent Salmonella Ty21a to the Bladder Epithelium.

ABSTRACT:

Background

Bladder cancer is the ninth most common cancer in men. 70% of these tumors are classified as non-muscle invasive bladder cancer and those patients receive 6 intravesical instillations with Mycobacterium bovis BCG after transurethral resection. However, 30% of patients show recurrences after treatment and experience severe side effects that often lead to therapy discontinuation. Recently, another vaccine strain, Salmonella enterica typhi Ty21a, demonstrated promising antitumor activity in vivo. Here we focus on increasing bacterial retention in the bladder in order to reduce the number of instillations required and improve antitumor activity.

Objective

To increase the binding of Ty21a to the bladder wall by surface labeling of the bacteria with

SUBMITTER: Burggraaf MJ 

PROVIDER: S-EPMC11181684 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature