Causality of genetically proxied immunophenotypes on cardiovascular diseases: a Mendelian randomization study.

ABSTRACT:

Background

Cardiovascular diseases (CVDs) stand as the foremost global cause of mortality, prompting a growing interest in using the potential of immune cells for heart injury treatment. This study aims to assess the causal association between immune cells and CVDs.

Methods

A total of 731 immune cells were derived from a previously published genome-wide association study (GWAS), which included approximately 22 million genetic variants among 3,757 individuals of Sardinian ancestry. Genetic associations with atrial fibrillation (AF), heart failure, coronary artery disease, myocardial infarction and stroke were extracted from large-scale GWAS. A two-sample Mendelian randomization (MR) analysis was used to assess the causal association between immune cells and CVDs. Replication

SUBMITTER: Wang X 

PROVIDER: S-EPMC11181691 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature