Effect of Bacille Calmette-Guerin for Non-Muscle-Invasive Bladder Cancer After Prostate Radiotherapy.

ABSTRACT:

Background

Little is known about the impact of prior prostate radiation therapy (RT) on the Bacille Calmette-Guerin (BCG) immunotherapy response in patients with non-muscle invasive bladder cancer (NMIBC).

Objective

We hypothesized that the damaging radiation effects on the bladder could negatively influence BCG efficacy.

Methods

Men with a history of high-risk NMIBC were identified within the Surveillance, Epidemiology, and End Results-Medicare database. All patients completed adequate BCG defined as at least 5 plus 2 treatments completed within 12 months. Patients were stratified into 2 groups: with prior RT for prostate cancer and without prior RT before the diagnosis of NMIBC. The primary endpoint was a 5-year composite for progression defined as disease progressi

SUBMITTER: Durant AM 

PROVIDER: S-EPMC11181702 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature