An Association Study of Germline Variants in Bladder Cancer-Related Genes with the Prognosis of Non-Muscle Invasive Bladder Cancer.

ABSTRACT:

Background

Various germline genetic variants are associated with the prognosis of non-muscle invasive bladder cancer (NMIBC). Germline variants in genes frequently somatically mutated in bladder cancer have not been studied thoroughly in relation to risk of recurrence or progression in NMIBC.

Objective

To identify germline DNA variants in bladder carcinogenesis-related genes associated with recurrence or progression in NMIBC.

Methods

We analysed associations between single-nucleotide polymorphisms (SNPs) and NMIBC recurrence and progression using data from the Nijmegen Bladder Cancer Study (NBCS, 1,443 patients). We included 5,053 SNPs within 46 genes known to have mutation, overexpression or amplification in bladder cancer. We included all recurrences in the statisti

SUBMITTER: Hof JP 

PROVIDER: S-EPMC11181778 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature