Potential of an mRNA-Based Urine Assay (Xpert^® Bladder Cancer Detection¹) in Hematuria Patients - Results from a Cohort Study.

ABSTRACT:

Background and objective

Assessment of patients with hematuria (aH) remains a challenge in urological practice, balancing the benefits of diagnosing a potentially underlying bladder cancer (UCa) against the risks of possibly unnecessary diagnostic interventions. This study analyzes the potential of an mRNA-based urine assay, the Xpert^® Bladder Cancer Detection- CE-IVD (Xpert BC-D), in patients with hematuria.

Materials and methods

Overall, 368 patients with newly observed painless hematuria and no history of UCa were included in this observational study. Patients received urological workup, including urethrocystoscopy (WLC), upper tract imaging, urine cytology and Xpert BC-D. Patients with positive WLC were recommended to undergo tumor resection (TUR-B).

Result

SUBMITTER: Schmitz-Drager C 

PROVIDER: S-EPMC11181824 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature