Evolutionarily divergent mTOR remodels translatome for tissue regeneration.

ABSTRACT: An outstanding mystery in biology is why some species, such as the axolotl, can regenerate tissues whereas mammals cannot¹. Here, we demonstrate that rapid activation of protein synthesis is a unique feature of the injury response critical for limb regeneration in the axolotl (Ambystoma mexicanum). By applying polysome sequencing, we identify hundreds of transcripts, including antioxidants and ribosome components that are selectively activated at the level of translation from pre-existing messenger RNAs in response to injury. By contrast, protein synthesis is not activated in response to non-regenerative digit amputation in the mouse. We identify the mTORC1 pathway as a key upstream signal that mediates tissue regeneration and translational control in the axolotl. We discover un

SUBMITTER: Zhulyn O 

PROVIDER: S-EPMC11181899 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature