G protein-coupled estrogen receptor expression in postnatal developing mouse retina.

ABSTRACT:

Introduction

Estrogen has emerged as a multifaceted signaling molecule in the retina, playing an important role in neural development and providing neuroprotection in adults. It interacts with two receptor types: classical estrogen receptors (ERs) alpha and beta, and G protein-coupled estrogen receptor (Gper). Gper differs from classical ERs in structure, localization, and signaling. Here we provide the first report of the temporal and spatial properties of Gper transcript and protein expression in the developing and mature mouse retina.

Methods

We applied qRT-PCR to determine Gper transcript expression in wild type mouse retina from P0-P21. Immunohistochemistry and Western blot were used to determine Gper protein expression and localization at the same

SUBMITTER: Pinon-Teal WL 

PROVIDER: S-EPMC11182193 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature