High salt diet alleviates disease severity in native experimental autoimmune uveitis.

ABSTRACT:

Background

Recent studies reported a link between high salt diet (HSD) and clinical exacerbation in mouse models of autoimmune diseases, mainly through the induction of pathogenic Th17 cells and/or HSD-induced dysbiosis. However, the topic remains controversial and not fully understood.

Purpose

In this study, we investigated the effects of HSD on the development of experimental autoimmune uveitis (EAU) in C57BL/6J mice.

Methods and results

Unexpectedly, our data showed a significant attenuating effect of HSD on disease severity of native EAU, induced by direct immunization with IRBP peptide. That said, HSD had no effect on EAU disease severity induced by adoptive transfer of semi-purified auto-reactive IRBP-specific T lymphocytes. Accordingly, HSD did not affect IRBP-

SUBMITTER: Derluyn N 

PROVIDER: S-EPMC11182228 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature