A highly neutralizing human monoclonal antibody targeting a novel linear epitope on staphylococcal enterotoxin B.

ABSTRACT: Staphylococcal Enterotoxin B (SEB), produced by Staphylococcus aureus (S. aureus), is a powerful superantigen that induces severe immune disruption and toxic shock syndrome (TSS) upon binding to MHC-II and TCR. Despite its significant impact on the pathogenesis of S. aureus, there are currently no specific therapeutic interventions available to counteract the mechanism of action exerted by this toxin. In this study, we have identified a human monoclonal antibody, named Hm0487, that specifically targets SEB by single-cell sequencing using PBMCs isolated from volunteers enrolled in a phase I clinical trial of the five-antigen S. aureus vaccine. X-ray crystallography studies revealed that Hm0487 exhibits high affinity for a linear B cell epitope in SEB (SEB₁₃₈

SUBMITTER: Fan H 

PROVIDER: S-EPMC11182437 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature