Peripheral blood platelet counts identify prognostically diverse clinical phenotypes in hepatocellular carcinoma.

ABSTRACT:

Background

The factors responsible for hepatocellular carcinoma (HCC) growth are not precisely known.

Aims

To study the clinical parameters associated with increases in maximum tumor diameter (MTD).

Methods

A new cohort of 944 prospectively accrued HCC patients was analyzed for large size associations.

Results

Patients were ordered into MTD terciles. Blood platelets, GGT and AST levels significantly increased and total bilirubin decreased with increase in MTD. Similar results were found only for platelets, in patients with low alpha-fetoprotein (AFP) levels, for whom biomarkers are scanty. Survival significantly decreased for patients with high platelet or GGT levels, even when AFP levels were low.Comparison of patients with low and high platelet levels showed

SUBMITTER: Carr BI 

PROVIDER: S-EPMC11182490 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature