Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages.

ABSTRACT: Adeno-associated virus (AAV) serotypes from primates are being developed and clinically used as vectors for human gene therapy. However, the evolutionary mechanism of AAV variants is far from being understood, except that genetic recombination plays an important role. Furthermore, little is known about the interaction between AAV and its natural hosts, human and nonhuman primates. In this study, natural AAV capsid genes were subjected to systemic evolutionary analysis with a focus on selection drives during the diversification of AAV lineages. A number of positively selected sites were identified from these AAV lineages with functional relevance implied by their localization on the AAV structures. The selection drives of the two AAV2 capsid sites were further investigated in a series of bi

SUBMITTER: Li L 

PROVIDER: S-EPMC11182496 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature