Genetic characterization of a captive marmoset (Callithrix jacchus) colony using genotype-by-sequencing.

ABSTRACT: The marmoset is a fundamental nonhuman primate model for the study of aging, neurobiology, and many other topics. Genetic management of captive marmoset colonies is complicated by frequent chimerism in the blood and other tissues, a lack of tools to enable cost-effective, genome-wide interrogation of variation, and historic mergers and migrations of animals between colonies. We implemented genotype-by-sequencing (GBS) of hair follicle derived DNA (a minimally chimeric DNA source) of 82 marmosets housed at the Southwest National Primate Research Center (SNPRC). Our primary goals were the genetic characterization of our marmoset population for pedigree verification and colony management and to inform the scientific community of the functional genetic makeup of this valuable resource. We used

SUBMITTER: Cole SA 

PROVIDER: S-EPMC11182716 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature