Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis.

ABSTRACT:

Background

Angiogenesis is critical for forming new blood vessels from antedating vascular vessels. The endothelium is essential for angiogenesis, vascular remodelling and minimisation of functional deficits following ischaemia. The insulin-like growth factor (IGF) family is crucial for angiogenesis. Insulin-like growth factor-binding protein 5 (IGFBP5), a binding protein of the IGF family, may have places in angiogenesis, but the mechanisms are not yet completely understood. We sought to probe whether IGFBP5 is involved in pathological angiogenesis and uncover the molecular mechanisms behind it.

Methods and results

IGFBP5 expression was elevated in the vascular endothelium of gastrocnemius muscle from critical limb ischaemia patients and hindlimb ischaemic (HLI) mice and hy

SUBMITTER: Song F 

PROVIDER: S-EPMC11182737 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature