Hippocampal mitophagy contributes to spatial memory via maintaining neurogenesis during the development of mice.

ABSTRACT:

Background

Impaired mitochondrial dynamics have been identified as a significant contributing factor to reduced neurogenesis under pathological conditions. However, the relationship among mitochondrial dynamics, neurogenesis, and spatial memory during normal development remains unclear. This study aims to elucidate the role of mitophagy in spatial memory mediated by neurogenesis during development.

Methods

Adolescent and adult male mice were used to assess spatial memory performance. Immunofluorescence staining was employed to evaluate levels of neurogenesis, and mitochondrial dynamics were assessed through western blotting and transmission electron microscopy. Pharmacological interventions further validated the causal relationship among mitophagy, neurogenesis, and behavior

SUBMITTER: Xu L 

PROVIDER: S-EPMC11183181 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature