Explorations on the antiviral potential of zinc and magnesium salts against chikungunya virus: implications for therapeutics.

ABSTRACT:

Background

Chikungunya virus (CHIKV), which causes chikungunya fever, is an arbovirus of public health concern with no approved antiviral therapies. A significant proportion of patients develop chronic arthritis after an infection. Zinc and magnesium salts help the immune system respond effectively against viral infections. This study explored the antiviral potential of zinc sulphate, zinc acetate, and magnesium sulphate against CHIKV infection.

Methods

The highest non-toxic concentration of the salts (100 µM) was used to assess the prophylactic, virucidal, and therapeutic anti-CHIKV activities. Dose-dependent antiviral effects were investigated to find out the 50% inhibitory concentration of the salts. Entry bypass assay was conducted to find out whether the salts affect vi

SUBMITTER: Davuluri KS 

PROVIDER: S-EPMC11183322 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature