Serum proteomic analysis uncovers novel serum biomarkers for depression.

ABSTRACT:

Objective

The identification of depression primarily relies on the clinical symptoms and psychiatric evaluation of the patient, in the absence of objective and quantifiable biomarkers within clinical settings. This study aimed to explore potential serum biomarkers associated with depression.

Methods

Serum samples from a training group comprising 48 depression patients and 48 healthy controls underwent proteomic analysis. Magnetic bead-based weak cation exchange (MB-WCX) and MALDI-TOF-MS were used in combination. To screen the differential peaks, ClinProTools software was employed. The proteins were identified using LC-MS/MS. ELISA was employed to confirm the expression of entire protein in the serum of the verification cohort, which encompassed 48 individuals who had been di

SUBMITTER: Guo A 

PROVIDER: S-EPMC11184055 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature