Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation.

ABSTRACT:

Introduction

We investigated the relationship between metabolic acidosis over time and allograft outcome in pediatric kidney transplantation (KTx).

Methods

This registry study collected data up to 10 years posttransplant. Survival analysis for a composite end point of graft loss or estimated glomerular filtration rate (eGFR) ≤ 30 ml/min per 1.73 m² or ≥50% decline from eGFR at month 3 posttransplant was performed. The association of serum bicarbonate concentration (HCO₃ ^-) < 22 mmol/l (metabolic acidosis) and HCO₃ ^- < 18 mmol/l (severe metabolic acidosis) with allograft outcome was investigated using stratified Cox models and marginal structural models. Secondary analyses included the identification of risk factors for m

SUBMITTER: Prytula A 

PROVIDER: S-EPMC11184248 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature