Longitudinal Changes in Kidney Solute Clearance in a Prospective Cohort of Patients Initiating Chronic Hemodialysis.

ABSTRACT:

Introduction

Longitudinal changes in residual kidney function have not been well-examined in patients starting chronic hemodialysis (HD).

Methods

We analyzed urine volume and kidney solute clearances from timed urine collections and corresponding plasma samples from 42 patients randomized to incremental HD (n = 21) and conventional HD (n = 21) in the TwoPlus pilot study. Samples were collected before HD initiation (baseline); and at 6, 12, 24, and 48 weeks. We assessed temporal trends in urine volume, kidney urea and creatinine clearance, and correlations between urine volume and kidney solute clearance.

Results

Residual kidney function parameters in all patients declined over time; the pattern of decline differed between urine volume and kidney solute c

SUBMITTER: Sirich TL 

PROVIDER: S-EPMC11184396 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature