Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure.

ABSTRACT:

Introduction

Blood pressure (BP) is a highly heritable trait with over 2000 underlying genomic loci identified to date. Although the kidney plays a key role, little is known about specific cell types involved in the genetic regulation of BP.

Methods

Here, we applied stratified linkage disequilibrium score (LDSC) regression to connect BP genome-wide association studies (GWAS) results to specific cell types of the mature human kidney. We used the largest single-stage BP genome-wide analysis to date, including up to 1,028,980 adults of European ancestry, and single-cell transcriptomic data from 14 mature human kidneys, with mean age of 41 years.

Results

Our analyses prioritized myofibroblasts and endothelial cells, among the total of 33 annotated cell type, as specifical

SUBMITTER: Ganji-Arjenaki M 

PROVIDER: S-EPMC11184402 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature