Social Environment, Lifestyle, and Genetic Predisposition With Dementia Risk: A Long-Term Longitudinal Study Among Older Adults.

ABSTRACT:

Background

The role of social environment, that is, the aggregate effect of social determinants of health (SDOHs), in determining dementia is unclear.

Methods

We developed a novel polysocial risk score for dementia based on 19 SDOH among 5 199 participants in the Health and Retirement Study, United States, to measure the social environmental risk. We used a survival analysis approach to assess the association between social environment and dementia risk in 2006-2020. We further studied the interaction between social environment and lifestyles, and explored racial disparities.

Results

The study participants (mean age = 73.4 years, SD = 8.3; 58.0% female; 11.6% African American) were followed up for an average of 6.2 years, and 1 089 participants developed dementia. Eve

SUBMITTER: Chen S 

PROVIDER: S-EPMC11184450 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature