Angiotensin Receptor Blockers for Hypertension and Risk of Epilepsy.

ABSTRACT:

Importance

Animal and human studies have suggested that the use of angiotensin receptor blockers (ARBs) may be associated with a lower risk of incident epilepsy compared with other antihypertensive medications. However, observational data from the US are lacking.

Objective

To evaluate the association between ARB use and epilepsy incidence in subgroups of US patients with hypertension.

Design, setting, and participants

This retrospective cohort study used data from a national health administrative database from January 2010 to December 2017 with propensity score (PS) matching. The eligible cohort included privately insured individuals aged 18 years or older with diagnosis of primary hypertension and dispensed at least 1 ARB, angiotensin-converting enzyme inhibitor (ACE

SUBMITTER: Wen X 

PROVIDER: S-EPMC11184499 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature