Association of Recipient APOL1 Kidney Risk Alleles With Kidney Transplant Outcomes.

ABSTRACT:

Background

Kidney transplant survival in African American recipients is lower compared with non-African American transplant recipients. APOL1 risk alleles (RA) have been postulated as likely contributors. We examined the graft outcomes in kidney transplant recipients (KTRs) stratified by APOL1 RA status in a multicenter observational prospective study.

Methods

The Renal Transplant Outcome Study recruited a cohort of incident KTRs at 3 transplant centers in the Philadelphia area from 1999-2004. KTRs were genotyped for APOL1 RA. Allograft and patient survival rates were compared by the presence and number of APOL1 RA.

Results

Among 221 participants, approximately 43% carried 2 APOL1 RA. Recipients carrying 2 APOL1 RA demonstrated lower graft survival compared with recip

SUBMITTER: Roy N 

PROVIDER: S-EPMC11184510 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature