Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization.

ABSTRACT: Dengue virus (DENV) nonstructural protein 5 (NS5), consisting of methyltransferase and RNA-dependent RNA polymerase (RdRp) domains, is critical for viral RNA synthesis within endoplasmic reticulum-derived replication complexes in the cytoplasm. However, a significant proportion of NS5 is localized to the nucleus of infected cells for DENV2, 3, and 4, whereas DENV1 NS5 is localized diffusely in the cytoplasm. We still have an incomplete understanding of how the DENV NS5 subcellular localization is regulated. Within NS5, two putative nuclear localization signal (NLS) sequences have been identified: NLS_Central residing in the palm of the RdRp domain as well as the recently discovered NLS_C-term residing in the flexible region at the C-terminal of the RdRp domain. We have

SUBMITTER: Cheng CX 

PROVIDER: S-EPMC11184549 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature