The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals.

ABSTRACT:

Background

The strongest risk factor for the development of Alzheimer's disease (AD) is age. The progression of Braak stage and Thal phase with age has been demonstrated. However, prior studies did not include cognitive status.

Objective

We set out to define normative values for Alzheimer-type pathologic changes in individuals without cognitive decline, and then define levels that would qualify them to be resistant to or resilient against these changes.

Methods

Utilizing neuropathology data obtained from the National Alzheimer's Coordinating Center (NACC), we demonstrate the age-related progression of Alzheimer-type pathologic changes in cognitively normal individuals (CDR = 0, n = 542). With plots generated from these data, we establish standard lines that may be uti

SUBMITTER: Walker JM 

PROVIDER: S-EPMC11184733 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature