Development of reciprocal connections between the dorsal lateral geniculate nucleus and the thalamic reticular nucleus.

ABSTRACT: The thalamic reticular nucleus (TRN) serves as an important node between the thalamus and neocortex, regulating thalamocortical rhythms and sensory processing in a state dependent manner. Disruptions in TRN circuitry also figures prominently in several neurodevelopmental disorders including epilepsy, autism, and attentional defects. An understanding of how and when connections between TRN and 1st order thalamic nuclei, such as the dorsal lateral geniculate nucleus (dLGN), develop is lacking. We used the mouse visual thalamus as a model system to study the organization, pattern of innervation and functional responses between TRN and the dLGN. Genetically modified mouse lines were used to visualize and target the feedforward and feedback components of these intra-thalamic circuits and to und

SUBMITTER: Campbell PW 

PROVIDER: S-EPMC11184795 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature