Dissemination of clinical Escherichia coli strains harboring mcr-1, bla_NDM-7 and siderophore-producing plasmids in a Chinese hospital.

ABSTRACT:

Background

Carbapenem-resistant E. coli (CREco) pose a significant public health threat due to their multidrug resistance. Colistin is often a last-resort treatment against CREco; however, the emergence of colistin resistance gene mcr-1 complicates treatment options.

Methods

Two E. coli strains (ECO20 and ECO21), recovered from hospitalized patients in distinct wards, exhibited resistance to carbapenems and colistin. Whole-genome sequencing and phenotypic characterization were employed to study resistance patterns, plasmid profiles, transferability of resistance and virulence genes, and siderophore production capabilities. Comparative genome analysis was used to investigate the genetic environment of mcr-1, bla_NDM-7, and virulence clusters.

Results

Both E.

SUBMITTER: Liu L 

PROVIDER: S-EPMC11184858 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature