Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients.

ABSTRACT:

Background

Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic variants within the DSB pathway remain underexplored.

Methods

In the present study, we performed a two-phase analysis of 19,290 single-nucleotide polymorphisms (SNPs) in 199 genes in the DSB repair pathway from a genome-wide association study (GWAS) dataset and explored their associations with overall survival (OS) in 1039 Han Chinese epithelial ovarian carcinoma (EOC) patients. After utilizing multivariate Cox regression analysis with bayesian false-discovery probability for multiple test correction, significant genetic variations were identified and subsequ

SUBMITTER: Li H 

PROVIDER: S-EPMC11184878 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature