Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APP^swe and PS1^dE9 mutations.

ABSTRACT:

Background

Neural progenitor cells (NPCs) can be cultivated from developing brains, reproducing many of the processes that occur during neural development. They can be isolated from a variety of animal models, such as transgenic mice carrying mutations in amyloid precursor protein (APP) and presenilin 1 and 2 (PSEN 1 and 2), characteristic of familial Alzheimer's disease (fAD). Modulating the development of these cells with inflammation-related peptides, such as bradykinin (BK) and its antagonist HOE-140, enables the understanding of the impact of such molecules in a relevant AD model.

Results

We performed a global gene expression analysis on transgenic neurospheres treated with BK and HOE-140. To validate the microarray data, quantitative real-time reverse-transcription pol

SUBMITTER: Juvenal G 

PROVIDER: S-EPMC11184896 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature