Longitudinal Microbiome Changes in Supragingival Biofilm Transcriptomes Induced by Orthodontics.

ABSTRACT:

Introduction

Common oral diseases are known to be associated with dysbiotic shifts in the supragingival microbiome, yet most oral microbiome associations with clinical end points emanate from cross-sectional studies. Orthodontic treatment is an elective procedure that can be exploited to prospectively examine clinically relevant longitudinal changes in the composition and function of the supragingival microbiome.

Methods

A longitudinal cohort study was conducted among 24 adolescent orthodontic patients who underwent saliva and plaque sampling and clinical examinations at time points: before fixed appliance bonding and at 1, 6, and 12 wk thereafter. Clinical indices included bleeding on probing (BOP), mean gingival index (GI), probing depths (PDs), and plaque index (PI). To s

SUBMITTER: Babikow E 

PROVIDER: S-EPMC11184915 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature