Comparison of genotypic and phenotypic antimicrobial resistance profiles of <i>Salmonella enterica</i> isolates from poultry diagnostic specimens.

ABSTRACT: The spread of antimicrobial-resistant bacteria is a significant concern, as it can lead to increased morbidity and mortality in both humans and animals. Whole-genome sequencing (WGS) is a powerful tool that can be used to conduct a comprehensive analysis of the genetic basis of antimicrobial resistance (AMR). We compared the phenotypic and genotypic AMR profiles of 97 Salmonella isolates derived from chicken and turkey diagnostic samples. We focused AMR analysis on 5 antimicrobial classes: aminoglycoside, beta-lactam, phenicol, tetracycline, and trimethoprim. The overall sensitivity and specificity of WGS in predicting phenotypic antimicrobial resistance in the Salmonella isolates were 93.4% and 99.8%, respectively. There were 16 disagreement instances, including 15 that were

SUBMITTER: Shen Z 

PROVIDER: S-EPMC11185115 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature