Exogenous NADH promotes the bactericidal effect of aminoglycoside antibiotics against <i>Edwardsiella tarda</i>.

ABSTRACT: The global surge in multidrug-resistant bacteria owing to antibiotic misuse and overuse poses considerable risks to human and animal health. With existing antibiotics losing their effectiveness and the protracted process of developing new antibiotics, urgent alternatives are imperative to curb disease spread. Notably, improving the bactericidal effect of antibiotics by using non-antibiotic substances has emerged as a viable strategy. Although reduced nicotinamide adenine dinucleotide (NADH) may play a crucial role in regulating bacterial resistance, studies examining how the change of metabolic profile and bacterial resistance following by exogenous administration are scarce. Therefore, this study aimed to elucidate the metabolic changes that occur in Edwardsiella tarda (E. tarda

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC11185186 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature