Effects of Tasks on Functional Brain Connectivity Derived from Inter-Individual Correlations: Insights from Regional Homogeneity of Functional MRI Data.

ABSTRACT: Research on brain functional connectivity often relies on intra-individual moment-to-moment correlations of functional activity, typically using functional MRI (fMRI). Inter-individual correlations are also employed on data from fMRI and positron emission tomography (PET). Many studies have not specified tasks during scanning, keeping participants in an implicit "resting" condition. This lack of task specificity raises questions about how different tasks impact inter-individual correlation estimates. In our analysis of fMRI data from 100 unrelated participants, scanned during seven tasks and in a resting state, we calculated Regional Homogeneity (ReHo) for each task as a regional measure of brain functions. We found that changes in ReHo due to tasks were relatively small compared with its

SUBMITTER: Di X 

PROVIDER: S-EPMC11185525 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature